The Genes behind Asthma

The Genes behind Asthma

Introduction

The mechanism of asthma is accompanied by the genetic and environmental factor that contributes to its chronicity and severity. There have been many recent studies that have contributed to the make a clear understanding of genetic determinants. So this can be understood as one of the most recent methods and the area of development in the human genetics since past few years. An overview has been presented by the Blumenthal (2005), there are now twenty chromosomal regions that are linked to the genetics of asthma.

Discussion

It is certain about the genes and asthma that there is no single asthma gene. There are number of genes which interact and then cause the receptiveness of asthma. It is possible that a person may have any of those genes to prompt her/him to the asthma without having any symptoms of it. The genetic research for asthma is very complicated because of several interactions among genetic predisposition, and environment. Despite of these complications researchers claim to find out several genes that are considered to be the cause of asthma. Though there are hundreds of such genes but here only the most discussed will be presented.

There are many types of genes for the asthma but a few common are known to man with the help of the medicine sciences. A few are: A Disinterring and Metalloprotease33 (ADAM 33), Interleukin-13, Interleukin-17F, Cysteinyl leukotrienes, Clara cell secretory protein (CC16), Inducible nitric oxide synthase (iNOS), Mast cell chymase (CMA1). All these are formed and are interpreted with the different methods and processes depending upon the type of disease and methods that could effectively identify it.

Most of the studies that are used to identify the asthma are based on the linkage studies. This involves the methods to identify the ADAM33, VDR, DPP10, PHF11, HLA-G, and GPR154. These genes are expected to be the part of atopy, elevated IgE levels, bronchial hyperresponsiveness, and other characters that are related to the asthma. Inspite of all the factors, the effects that are evident by the each gene of the asthma is relatively small. So the methods that are accompanied by the specified chromosomal regions are used in order to detect the presence of the asthma genes. Most of the researches to determine the methods regarding the Asthma in the modern methods for the genes testing of the asthma are following.

Genome Scan

This is the process in which the DNA is extracted from the SLSJ participants in order to test it against the patients of asthma. This is followed by the use of QIAGEN genomic purification procedure. The process of the Genotyping is carried out by the use of 367 autosomal and 21 X-chromosome microsatellite markers that are placed in the evenly manner all the way through the genome. The spacing used is almost 9.2 cM approx. The marker that is used is the modified apparatus of the Cooperative Human Linkage Centre Screening Set that is used to find the scan and the is set ...