PHENYTOIN IN TREATING EPILEPSY

Phenytoin in treating epilepsy



Phenytoin in treating epilepsy

Introduction

Investigations on the pharmacokinetics of phenytoin in the older literature are largely represented by acute rather than steady-state studies, which generally use low doses most likely to be associated with a shorter half-life. In addition, few studies of patients in the older age category (i.e. over 84 years), when the metabolism of drugs may change (Bourgeois, 2006, 33).

Discussion and Analysis

Recent studies have focused on phenytoin differences in patient population and individual drug metabolism, often for chronic drug use. Pharmacogenetic influences on drug metabolism are well liked, with polymorphisms in the gene ...