CATAMENIAL EPILEPSY

CATAMENIAL EPILEPSY



CATAMENIAL EPILEPSY

Introduction

Eatamenial subtype of epilepsy, epilepsy, which is a chronic neurological status distinuished recurrent seizures. Catamenial epilepsy is a subset of this community, which encompasses women about who they lock escalation in accordance with their menstrual cycle. Women with catamenial epilepsy strangely susceptible to endogenous hormonal changes. This seizure exacerbation has a statistically significant positive association of serum estradiol / estrogen classes and relations. With at least Greek times, there have been reported study of women with epilepsy and its relation to the menstrual cycle. These templates can be easily seen in the graphs of menstruation, despite the arrest and incident type. (Www.epilepsy.org.uk) Pathophysiology

Our understanding of the sex hormones estrogen, progesterone and testosterone increased significantly in the last century. These hormones are synthesized in various positions in the body, covering the ovaries, adrenal glands, liver, subcutaneous tissue, and the mind. There are many studies indicate that these steroid hormones take part in an important function in the pathophysiology of epilepsy. Extensively characterized, estrogen, and many species are considered "proconvulsant", and progesterone is considered the "anticonvulsant". (Buterbaugh, 1999) Estrogen

Estrogen can be detected in a woman's body in various styles, each of which is the power of women with catamenial epilepsy. Estrone (E1), estradiol (E2) and estriol (E3) three major circulating estrogen in the body. These three types of neuronal excitability of the levers, but very little is known about the interaction between the hormone, the ratio of the concentrations and ratios E1/E2/E3 and how it can enhance the behavior of seizure frequency in women with epilepsy. In normally menstruating women, serum estradiol classes are normally present on the 10 th day of the menstrual cycle and continued until ovulation. (Bauer et al., 1992) • The main source of estrone is adipose tissue (subcutaneous fat), where it is formed by aromatization of androstenedione. Estrone is the only estrogen after menopause, and this hormone can be very powerful in capturing the team menstrual woman unless she drastically overweight or obese. • Estradiol, includes the most prolific ligand estrogen receptor in the female body, especially in non-pregnant women, and more productive activator of estrogen receptor function than estrone and estriol. Estradiol increases is NMDA-receptor-mediated glutamate holding in neural membranes. With this tool, hippocampal CA1 pyramidal neurons are excited, and repetitive explosive response is induced. Dendritic spine density on hippocampal CA1 pyramidal units depends on the estradiol classes showing a direct connection through the normal fluctuations during the menstrual cycle. Estradiol has been shown that direct their fluctuations in dendritic spine density of hippocampal units using the tool that needs activation of the receptor NMDA. In addition, Duke contends that estradiol may therefore further increase of excitatory input in CA1 neurons.

(Professionals.epilepsy.com) through numerous forms of animal and human use of estrogen therapy hormone, estrogen was found to increase the excitability of neurons, the Prime Minister to reduce seizure threshold. In mature female rats separate unproven tests limbic seizure threshold varies inversely to estradiol classes throughout the estrous ...