Health-Related Quality Of Life (HRQL) is an essential health care indicator for persons who live with chronic illnesses. Studies consistently show two major dimensions of HRQOL: physical and mental.1,2 HIV infection and substance use disorders are chronic diseases with overlapping morbidity and complex contributions to decreased HRQOL. Greater understanding of how substance use affects HRQOL may identify targets for improving HRQOL in persons living with HIV. Compared with general population norms, physical and mental HRQOL are lower among persons living with HIV infection. (Lorenz, 2006, 952)