The melting and dissolution of drug delivery coating



ACKNOWLEDGEMENT

This project would have never been possible without the support of several individuals. I would like to express my sincere gratitude to my supervisor, Dr. Andrew Rosenthal, whose encouragement, supervision and support from the preliminary to the concluding level enabled me to develop an understanding of the subject. I was privileged to experience a sustained enthusiastic and involved interest from his side. It is through the numerous discussions that I have had with him that I was able to come up with many of the ideas that are presented. Therefore, I am very appreciative to my supervisor's interest and input into this project. I say thank you to the Food Group Centre for the undeserved opportunity given to me to use their laboratory for this project and also for their occasional professional and insightful advice when things proved difficult. Lastly, Collective and individual acknowledgments are also owed to my colleagues at OBU whose present somehow perpetually refreshed, helpful, and memorable.

My heartfelt thanks go to Dr Caroline Griffiths for her time and continuous intuitive and professional guidance which has all along been singularly indispensable in completing this work. However, I would like to express my utmost gratitude to my tutor Dr Simon Baker, Dr Tony Bradshaw and all of the school of life sciences staff for their immense contribution from initial proof reading the manuscript to offering a warm and friendly advice when needed. They gave me a lifetime, unforgettable memory of their intelligence, diligence and erudition.

Signature: _______________________________

Date: __________________________

DECLARATION

I, the undersigned, hereby declare that the work presented in this project titled, “The melting and dissolution of drug delivery coating” submitted towards completion of Bachelor of Science degree in Biomedical Science requirement during winter semester at Oxford Brookes University is my original work. It is an authentic record of my original work pursued under the guidance of Dr. A. Rosenthal. Therefore, I have not submitted the matter embodied in this project for the award of any other degree, institution and journal. All the sources I have used or quoted have been indicated by means of completed references.

Signed: __________________. Date: _________________.

Abstract

The Food Group Centre proposes to find the most suitable melting temperature for cocoa butter. The aim of the study is to investigate the melting and dissolution of the drug delivery coatings. The project is located in the Food Group Centre laboratory in room S403 and is being supervised by Dr. Rosenthal. By using the differential scanning calorimeter technique I will be able to collect relevant data for processing, analysis and interpretation. I will be trained to use the differential scanning calorimeter (DSC) over the summer holidays. Finally, the project got underway in May, 2011 and is scheduled for completion in April 2012. The ultimate goal of the project is to collect relevant data on gelatin capsules and cocoa butter. A literature search was conducted from May 2011 to April 2012.It focused on the key words dissolution, melting, gelatin, capsules, cocoa butter, drugs, thermal and solubility in order to identify the drug delivery coating options available. A random sample for drug coatings was ...