Melting and Dissolution of Drug Delivery Coatings



DECLARATION

I, the undersigned, hereby declare that the work presented in this project titled, “The melting and dissolution of drug delivery coating” submitted towards completion of Bachelor of Science degree in Biomedical Science requirement during winter semester at Oxford Brookes University is my original work. It is an authentic record of my original work pursued under the guidance of Dr. A. Rosenthaal. Therefore, I have not submitted the matter embodied in this project for the award of any other degree, institution and journal. All the sources I have used or quoted have been indicated by mean of completed references.

ACKNOWLEDGEMENTS

This research was funded by Oxford Brookes University. I wish to thank the Department of Biomedical Science Food Group Centre, Oxford Brookes University for access to a dissolution scanning calorimeter. Dr. Andrew Rosenthaal is acknowledged for his assistance in obtaining the microscopy images.

External: This project would have never been possible without the support of several individuals. I would like to express my sincere gratitude to my supervisor, Dr. Andrew Rosenthal, whose encouragement, supervision and support from the preliminary to the concluding level enabled me to develop an understanding of the subject. I was privileged to experience a sustained enthusiastic and involved interest from his side. It is through the numerous discussions that I have had with him that I was able to come up with many of the ideas that are presented. Therefore, I am very appreciative to my supervisor's interest and input into this project.

I say thank you to the Food Group Centre for the undeserved opportunity given to me to use their laboratory for this project and also for their occasional professional and insightful advice when things proved difficult. Lastly, Collective and individual acknowledgments are also owed to my colleagues at OBU whose present somehow perpetually refreshed, helpful, and memorable.

Internal: My heartfelt thanks go to Dr Caroline Griffiths for her time and continuous intuitive and professional guidance which has all along been singularly indispensable in completing this work. However, I would like to express my utmost gratitude to my tutor Dr Simon Baker, Dr Tony Bradshaw and all of the school of life sciences staff for their immense contribution from initial proof reading the manuscript to offering a warm and friendly advice when needed. They gave me a lifetime, unforgettable memory of their intelligence, diligence and erudition.

SUMMARY

The Food Group Centre proposes to develop a model project for impacting high risk youth entitled a Chance for Youth. The project aimed at the effect of melting and dissolution on the delivery of drug. The project is located in the Food Group Centre laboratory room S403 and is been supervised by Dr. Rosenthal. By using a technique called dissolution scanning calorimetry techniques I will be able to collect and analyse my data. I will be trained to use the differential scanning calorimeter (DSC). Finally, the project is targeted to begin the summer holidays during May, 2011 and last through winter semester in ...