TAP1 and TAP2 Genes

1. Explain why the mutation in the TAP2 genes leads to significantly decreased levels of both class I MHC molecules and CD8+ T cells.

The cantered tenet of the immune scheme is the proficiency to identify and eliminate non-self constituents without influencing self components. The T units and B units of the immune scheme articulate a huge repertoire of antigen receptors.

1 a: Maruya (11) displayed that T units bearing receptors encompassing a constituent of the Vb17 family were missing from mice expressing the MHC class-II molecule I-E, with which the Vb17 string of connections is reactive. CD8+ thymocytes bearing ...