SYSTEMIC LUPUS ERYTHEMATOSUS

Systemic Lupus Erythematosus (SLE) is an Example of an Autoimmune Disease. Explore the Pathogenesis of this Condition and its Potential Effects upon the Foot and Lower Limb



Systemic Lupus Erythematosus (SLE) is an Example of an Autoimmune Disease. Explore the Pathogenesis of this Condition and its Potential Effects upon the Foot and Lower Limb

Introduction

Systemic Lupus Erythematosus (SLE) is a rare disease. Only by prominent people who suffer from this autoimmune disease and have them made public, the disease has been reported. For instance, known among other things, Lady Gaga and Seal sufferers. This lupus erythematosus has also become a broad stratum of the population is now known. Very few people know is what it is in this disease.

It is known that it is the disease is a so-called autoimmune disease. The body's immune system or is directed at the disease from their own bodies, or our own tissue. Unknown, however, why the immune system is aimed at people concerned with the body that take place while in others no reaction to the body's own tissues.

Discussion

Systemic Lupus Erythematosus (SLE) is a multisystem disease of unknown etiology, characterized by the production of autoantibodies, which occurs in susceptible hosts in which there is probably an alteration in lymphocyte homeostasis and peripheral tolerance induced by or associated to a increased apoptosis and defective clearance of self antigens generated.

Asanuma (2003, p. 14) discusses the mechanism responsible for the breakdown of tolerance in SLE ??remains unknown even though in recent years there has been significant progress in understanding the molecular interactions regulating the expansion of B and T cells reactive self. Most normal individuals have antibodies in their serum IgM anti-single stranded DNA. The process by which the response of T and B lymphocytes to an antigen is expanded to include additional reactivity to antigens depends on the degeneracy of the antigen receptor of T cells so that a single receptor binds to a complex peptide HLA and therefore a T or B cell activated by a single antigen respond to multiple antigens and not self self antigens. Through this mechanism, multiple exposure to bacterial antigens, viral or chemical or self antigens can lead to the formation of antibodies to DNA. Tolerance is the process by which cells eliminate or neutralize reactive self and the failure of this system in genetically susceptible individuals can lead to autoimmunity.

Meanwhile T cells which play a dominant role in tolerance and autoimmunity development are central and peripheral mechanisms for the development of tolerance. T cells whose receptors have low affinity for these complexes do not receive signals that prevent spontaneous apoptosis in the thymus die. Syuto (2009, p. 5)The MPS is dependent on the receptors for complement receptors recognizing the Fc portion of immunoglobulin (Ig) or Fc receptors (FcR) and Igs conveyors. Abnormal processing of immune complexes may play an important role in the pathogenesis of SLE in different ways, including abnormalities in the mechanisms of transport or presentation defects in the function of the MPS 37 ...