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Sickle Cell Disease


Sickle Cell Disease Sickle Cell Disease

Sickle Cell Disease

The sickle cell diseases (SCDs) affect approximately 72 000 individuals in the United States. Sickle cell disease (SCD) is a genetic set of disorders identified by a entire or partial substitution of usual hemoglobin (HgbA) with atypical hemoglobin S (HgbS). Acute painful vaso-occlusive episode (VOE) is the most observed expression of sickle cell disease and is the most common reason of hospital care requirements for adults with sickle cell disease. The episodes of pain are initiated by inactivity of sickle-shaped erythrocytes; the cells occlude the microcirculation, imitating ischemia and infarction. Acute painfulness, frequently associated ...
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