RESEARCH ARTICLE ANALYSIS

Research Article Analysis



Research Article Analysis

1-2.

The adverse effects of lapatinib most frequently encountered in this study are diarrhea, nausea and vomiting, fatigue, headache, back pain, rash and hand foot syndrome. By cons, lapatinib is known for its risk of cardiotoxicity. The purpose of the paper is based on this concept and its main objective is to check the risk of toxicity in patients having been treated previously with an anthracyclinecardiotoxic agent, and heart failure.

3-4.

This is a randomised control trail study and compares lapatinib plus capecitabine with capecitabine alone in breast cancer patients on the basis of quantitative data and analysis. Randomization control trial is an allocation method of random groups of patients and treatment, which provides the greatest similarity as possible between groups for all the known and unknown factors related to patients and may influence the result a study. Most studies conduct a completely randomized design in which each patient has equal opportunity to receive treatment.The strength of this research design is that the evaluation of the patients is performed by independent reviewers and under blind conditions. The limitation in the study is open table design. This knowledge can bias the result as both the members know about the treatment.

5-8.

The total of 324 breast cancer patient were recruited for randomization in two groups with a distribution 1:1, out of which 163 received combination therapy and the remaining 161 received mono therapy every 3 week. 16 patients have not received therapy assigned then of the randomization by poor interpretation of the code by the institution and 8 patients never received treatment after randomization. The authors calculated that more of 266 events were necessary for a 90% power and detect an increase in time median increase of 50% or more. The highest death rate from breast cancer is usually ...