In the context of spatial systems the concepts of networks, nodes and links appear to be rather ambiguous; in particular, the concept of ''Cities' Network'' (but also the concepts of urban networks, poly nuclear urban systems, etc., often used interchangeably although there are substantive differences between them) can be used differently as a political or economic concept or an empirical concept, or as a theoretical model, as a metaphor but also in other ways. This creates conceptual confusion and generates significant uncertainties in theoretical and applied cities' network analysis and management.