This case analysis, focused on evaluation and administration in children , will not distinguish between TTP and HUS but, rather, will use the period TTP-HUS to describe all patients. The presence or absence of acute renal malfunction may be significant for prognosis, but the heterogeneity amidst TTP-HUS syndromes in adults is much larger than this single distinction. Children with TTP-HUS caused by quinine or ticlopidine hypersensitivity, or an enteric infection with bloody diarrhea typically respond promptly and completely.