Wilson's Disease

Wilson's Disease

Abstract

These papers are aim to define the concept of Wilson disease and existence of copper in the body, which is the major source of this disease. It was in 1912, when Kinnier Wilson described the classic form of the disease, and calling it progressive lenticular degeneration. These papers are describing that copper is found in several foods and small proportions and sometimes, it becomes essential for the proper functioning of organism. The consequences of abnormal activity of this disease is reduced due to excretion of copper, and its excessive accumulation in the body may cause damage to organs including liver and brain (Cox, and Roberts, 2006). Secondly, papers are discussing clinical presentations of Wilson's disease. In these papers, clinical symptoms of this diseases are described as it may be different the first are usually between 10 and 40 years of age most concern liver dysfunction (approximately 40% of cases), often there are neurological symptoms (40%), and less psychiatric (15%). In younger patients, the first symptoms are usually a problem with liver, while in older it is because of neuropsychiatric.

These papers are describing that under certain circumstances, there may be a huge intake of copper than usual intake, yet eliminating the copper healthy subjects that do not require at certain level. It is also noticed in the paper that Wilson's disease patients do not perform this process spontaneously. From these papers, it is identified that in patients, copper buildup begins soon after their birth. The excess of copper affects the liver and brain, causing hepatitis and neurological and psychiatric symptomatology. Clinical manifestations usually appear in late adolescence (Cox, and Roberts, 2006). Patients may present with liver disease or abnormal functioning of this organ, jaundice, abdominal swelling, vomiting blood or stomach pain. These papers also summarize motor abnormalities that also be ...