Troponin for Cardiac Function

Troponin for Cardiac Function

Cardiac Troponin

Troponin is a complex protein that sensitizes cells muscle to calcium. Troponin is a complex of three regulatory proteins (troponin C, troponin I and troponin T) that is integral to muscle contraction in skeletal and cardiac muscle, but not smooth muscle. Discussions of troponin often pertain to its functional characteristics and/or to its usefulness as a diagnostic marker for various heart disorders. Troponin is a heterotrimeric protein. There are three distinct subunits in the troponin:

Troponin C (TnC)

This subunit is responsible for binding with calcium . Once the bound calcium troponin calcium moves and ceases to prevent binding between myosin and actin. TnC has a strong similarity between the shape heart and skeletal shape, making it impossible to obtaining monoclonal antibodies and excluding any clinical relevance. Troponin C is capable of binding calcium ions and complex active subunit. Joining the subunits is Tn I and Tn T, but does not interact with actin and tropomyosin with.

Troponin I (TnI)

This subunit is responsible for the inhibition of the binding between actin and myosin (masking the site of actin which serves to connect with the myosin). It has a function that inhibitory effect of initiating muscle relaxation. TnI has three isoforms, respectively specific skeletal muscle fast twitch muscle (muscle fibers consisting essentially of type 2 (white)), the slow-twitch skeletal muscle (muscle muscle fibers composed substantially of Type 1 (red fibers)) and heart (cTnI).

Troponin T (TnT)

This subunit is responsible for binding with tropomyosin. TnT exists in skeletal isoforms 5-12 (TnTs) and 4 cardiac isoforms (cTnT).

Structure

Each of the three subunits are almost globular tertiary structure (except for the C subunit, which has a double helical fibrous portion globular ends) and receive a specific name which is directly related to the functional feature are performed. Thus, the protein comprises troponin T, R and C respectively and approximate molecular weights of 37, 23 and 18 kilodaltons. The troponin T (Tn T) receives this name because its function is to set the protein complex to tropomyosin . Subunit is the majority of the protein and is present in two cell fractions: a soluble frees in the cytoplasm and attached to another fibrillar system. There are three isoforms of Tn T that differ in 6 to 11 amino acid residues that are highly polar. The troponin T type 1 (TNNT1) present in the skeletal muscle of slow twitch troponin T type 2 ( TNNT2) located in the heart muscle, and troponin T type 3 (TNNT3) acting in fast-twitch skeletal muscle.

Troponin Test for Cardiac Function

Increased troponin is however delayed with respect to pain even in the case of a stroke, the blood test may be normal before the sixth hour after pain. This diagnosis can not be eliminated by two successive negative dosages every few hours. The benchmark treatment in myocardial is the clearing of the coronary artery, made as soon as possible and ideally before the sixth hour of the onset of symptoms. The diagnosis of this disease in the ...