SUMMARY

The New England Journal of Medicine

The New England Journal of Medicine

Summary

The study “Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand” was conducted by Rerks-Ngarm et al in 2009. The objective of the study was to evaluate the effectiveness of vaccine in pandemic control of HIV-1. The study described that in the late 1980, dramatic increase of HIV-1 was found in Thailand. It was also described by the study that this vaccine was initially used by people with any addiction and sex workers. Both of them used this virus to protect themselves. It was about 1995, when the overall seroprevalence of this virus reached at its height. This increased was recorded around 3.7% among the general perception. The protocol of the study was ethically reviews by the ethics committees of the ministry of public health and various organisations. The conducted study was a community based and randomized multicenter trial. Moreover, this study was placebo controlled and double blind trial. The study evaluated the four basic injections of the recombinant canary pox vector vaccine. Moreover, the study also evaluated the two booster injections that were composed of recombinant glycoprotein with 120 subunits of vaccine.

The vaccine and injections of placebo were injected and administered into around 16,500 men and women. The age groups of the people were about 18 to 30 years. The people were selected from Rayong and Chan Buri provinces situated in Thailand. Moreover, those peoples and volunteer that are at heterosexual risk for the injection were assessed with the help of the co-primary end points. These co-primary end points were included HIV 1 injection and early HIV1 viremia. The study vaccines were injected during the time periods of 0 weeks, 4 weeks, 12 weeks, and 24 weeks. This vaccine was injected during the four major visits. Boosting ...