Scientific Paper Review



Scientific Paper Review

The 5-HT2C receptor interacts with many intracellular proteins in addition to G proteins and ß-arrestins. To date, the 5-HT2C receptor is certainly the GPCR for which interacting proteins have been the most extensively characterized by mean of proteomic approaches This paper biochemically characterized the interaction between CaM and the 5-HT2C receptor C-terminal domain, and we provide evidence of an essential role of this interaction in 5-HT2C receptor-mediated ERK1,2 signaling. The roles that interaction with CaM plays in receptor function are remarkably diverse. Depending on the GPCR, CaM interaction with the receptor can affect its coupling with ...