Neuropharmacy

Unusual interactions of benzodiazepine receptor antagonists

Unusual interactions of benzodiazepine receptor antagonists

Introduction

The way paved for the advancement studies in the field of biological sciences by the studies of the 1980s and 1990s has continued to explore the new dimensions of conducting research in the respective field. The empirical evidence provides the back support to the academic conclusions and helps one to see the biological structure of mammals (including animals and human beings) from newly discovered aspects. These research and practical findings bring humanity close to understand the mechanism of nature.

The discovery of an unusual interaction of the BDZ receptors was done in the initial years of the 1980s, however, the researchers coming later in this field continued the link of experiments from the same point where it was left and explored new behaviours and actions of the antagonistic receptors of BDZ. Several studies have critically analyzed the continuously evolving behaviour of the GABAA BDZ receptor.

Experimental studies on animals and humanity help to understand the differences in the mechanism and natural structure of the two creatures. This assignment has highlighted the experimental setup arranged to observe the unusual behaviour of the receptors of BDZ. It also explained the findings of this experiment along with the observed characteristics of the two compounds.

A hypothesis statement has been made to support the practical approach of the assignment along with the concluding observations and proposed mechanisms in the end of the experimental findings. An effort is made to present the related discovering about the two compounds (Ro 15-1788 and beta-CCE), and their changing behaviour, in this field. It includes the chronic treatments done with the Ro 15-1788 on a group of men and the experimental study conducted with monkeys to observe the characteristics of beta-CCE. An article has been short storied to highlight the importance of working in a style of journalism with a relevant image that supports the research objective and findings.

Hypothesis

A hypothesis identifies and clearly states the expected relationship between two or more variables. It is a clear and concrete statement of the expected outcome of a study. Rather than to be proven, hypothesis is used as a testifying tool to support the basis of a specific research. There are two hypothesis proposed for the topic understudy including null hypothesis and alternative hypothesis (www.sagepub.com).

The proposed hypotheses were testable and proven by the experimental findings of this research (www.sagepub.com). The two compounds have different action profile hence; their actions can be observed in two different systems. The experimental working of both the compounds on rat indicates that they are the antagonists of BDZ lowering the seizure threshold (Nutt et. al., 1982, p. 436).

The null hypothesis stated that the compounds Beta-CCE and Ro 15-1788 did not show high affinity and selectivity for the BDZ receptors of the mammalian Central Nervous System (CNS) where as the alternative hypothesis proposed that the compounds Beta-CCE and Ro 15-1788 show high affinity and selectivity for the BDZ receptors of the mammalian Central Nervous System (CNS) (Yliniemelae, 1989, ...