Meclizine is neuroprotective in models of Huntington's disease

Introduction

Defects in cellular energy metabolism represent an early feature in a variety of human neurodegenerative diseases. Recent studies have shown that targeting energy metabolism can protect against neuronal cell death in such diseases. Here, this study show that meclizine, a clinically used drug that this study have recently shown to silence oxidative metabolism, suppresses apoptotic cell death in a murine cellular model of polyglutamine (polyQ) toxicity. This study further show that this protective effect extends to neuronal dystrophy and cell death in Caenorhabditis elegans and Drosophila melanogaster models of polyQ toxicity. Meclizine's mechanism of action is not attributable to its anti-histaminergic or anti-muscarinic activity, but rather, strongly correlates with its ability to suppress mitochondrial respiration. Since meclizine is an approved drug that crosses the blood-brain barrier, it may hold therapeutic potential in the treatment of polyQ toxicity disorders, such as Huntington's disease.

Defects in cellular energy metabolism Represent year early feature in a Variety of human neurodegenerative diseases. Recent Studies Have Shown That Can targeting energy metabolism Protection against neuronal cell death in Such diseases (Sari, Pp 2). Here, this study show That meclizine, a Clinically Used Drug That This study Have Recently Shown to silence oxidative metabolism, suppresses apoptotic cell death in a murine model of cellular polyglutamine (polyQ) toxicity. Further this study show this protective effect extends that to neuronal dystrophy and cell death in Caenorhabditis elegans and Drosophila melanogaster models of polyQ toxicity. Mechanism of action Meclizine's is not it's to attribute anti-histaminergic or anti-muscarinic activity, purpose Rather, Strongly Correlates with Ability to suppress icts mitochondrial respiration. Since meclizine(Doris et al, P 3) That Is An Approved drug crosses the blood-brain barrier, hold it May therapeutic Potential in the Treatment of polyQ toxicity disorders, Such as Huntington's disease.

Findings of the Research

Huntington's disease, also known as HD, is a genetic deterioration of brain cells called neurons in certain parts of the brain. This degeneration causes loss of motor control, dementia and personality changes. Particularly affected the nerve cells in the basal ganglia and cortex, which have many important functions - such as coordination of movements. HD is an inherited genetic disease. It is inherited from parent to child with an abnormality in the genes.

Methodology

Genetic tests can show a complete course of illness and neurological tests and laboratory tests to help diagnose the disease HD. A predictive diagnostics is available for persons at ...