Investigation into the Link between Dietary Fibre and Incidence of Bowel Cancer

Investigation into the Link between Dietary Fibre and Incidence of Bowel Cancer

Genomic damage resulting in aberrant gene expression is the fundamental cause of all cancers. Such damage includes mutations, aberrant epigenetic marking, chromosomal damage and telomere shortening. During cancer development, a number of tumour suppressor genes are silenced (by both mutations and by epigenetic mechanisms) and oncogenes are inappropriately expressed. Whilst much of the research focus has been on damage to nuclear DNA, more recent evidence suggests that damage to the mitochondrial genome may also play a role in tumorigenesis. ...