Inflammation Mediators and Manipulation

Inflammation Mediators and Manipulation

Introduction

Different types of outcome measures have been employed in developing a better understanding and monitoring of treatment course related to that of chiropractic adjustments. Two major outcomes measures related to the treatment course of chiropractic adjustments are inflammation markers interleukin-6[IL-6] and C-reactive protein [CRP] but no research or study has been conducted so far to find any type of relationship between the inflammation markers and manipulation. Inflammatory process is related to the lower back pain and is suggested to be followed by different cytokines plasma expression. Inflammation consist of two important plasma cytokine that are proinflammatory cytokines namely IL6 and CRP. IL-6 has been reported to be as the main mediator of the acute inflammatory phase of lower back pain while some authors suggest CRP as the sensitive marker of inflammation. Research shows that single chiropractic treatment of the lower back pain does have a profound effect on circulation of certain types of cytokines but not all of them. It has been reported to affect the circulation of tumor necrosis factor-á and interleukin-1 but not substance P and interleukin-2. Therefore currently, certain spinal interventions are being used to deal with lower back pain issues combined with a mechanical force that is manually assisted by lumbar spine protocol.

Objective

The main purpose of this study is to analyze and examine the effect of 9 different types chiropractic spinal manipulations or exercises on the two important cytokines expressions namely IL-6 and CRP. Since no study has been conducted on these two expression to find their relations with each other or with lower back pain. This study will analyze their relationship with the lumbar spinal manipulations to fine the significance and role that these two cytokines expression may play in the treatment and recovery from lower back pain.

Materials and Methods

Population

The population was divided into two groups on the basis to treatment and their condition, control group and treatment group. in control group there were 10 participants in total out which 4 were women and 6 were men. While in treatment group there were 10 participants out of which 3 were women and 7 were men. A total of 21 subjects were selected for this study.

Inclusion Criteria

Control Group: subject of this group was examined through complete physical check up , blood groups and spinal radiographs to ensure that they were pain free and healthy. they were selected from chiropractic clinic and it was made sure that they do not receive any other type of treatment for the period of two weeks.

Treatment Group: they were select through advertisements in a newspaper and their inclusion criteria was that they must have lower back pain condition for the period of 3 months at least.

Measures

Initially there were total of 21 participants 10 in control group and 11 in treatment group but one female participant from the treatment group did not show on the examination day so the treatment group was reduced to 10 and the total population was reduced to 20 subjects to be more ...