GLIPIZIDE

GLIPIZIDE

Abstract

In this study, we try explore about the Glipizide from a holistic point of view. This Research report includes all the basic information about Glipizide, its potential patients and alternatives in the market. This Research also looks into the manufacturers of this drug and all the medicines which use this drug as their component.

Table of Contents

Introduction4

About Glipizide5

International Products6

Dosage for Glipizide8

Side effects of Glipizide9

Precautions and warnings for Glipizide10

Other alternative of Glipizide11

Conclusion13

Introduction

This research paper is about a drug called Glipizide. It is an oral drug which is normally used for the treatment of those patients who are suffering from type 2 diabetes. Glipizide basically branches out of the class of sulfonylurea drugs, which also comprises of drugs like glimepiride, glyburide, tolazamide and tolbutamide. Before going into the details of Glipizide, we need to understand the disorder for which it is used. As mentioned earlier, it is used for patients who are suffering from type 2 diabetes. Insulin is a kind of hormone which is generated in pancreas and then it is discharged into the blood which allows the blood cell to remove glucose (sugar) from the blood and even controls the production / formation of glucose through liver. If we talk about the patients who are suffering from type 2 diabetes, the nature of disorder with them is that their liver produces excess glucose and their blood cells are actually resistant towards the anti-glucose reaction of insulin. Apart from the liver producing excess glucose, another disorder faced by those who are suffering from type 2 diabetes is that pancreas is not capable to construct the optimum level of insulin which is required by the blood cells to overcome the resistance. In this whole scenario, Glipizide is a drug which performs the function of stimulating the pancreas to generate more insulin in order to reduce the blood glucose level. This drug is not a cure for type 2 diabetes or any type of diabetes for that matter, the purpose of its consumption is to control the level of glucose, hence keeping diabetes under control. Glipizide was approved by Food and Drug Administration (FDA) in May 1984, after which it was used for numerous medicines.

About Glipizide

The therapeutically Glipizide is classified as an Anti-diabetic drug which counters diabetes by lowering the level of glucose produce in the blood cells. With the exception of injectables, all the anti-diabetics are consumed orally. Overall there are different kinds of Anti-Diabetics and their classification and uses depend on the type of patient who is using it.

As far as the mechanism of action for Glipizide is concerned, Sulfonylurea in correspondence with ATP-sensitive potassium-channel receptors, which are present at the pancreatic cell surface, allows depolarization of the membrane and reduction of potassium conductance. The depolarization of the membrane stimulates the influx of calcium ion through voltage sensitive calcium channels. This leads to the raising of intracellular concentration of calcium ions; which encourages the emission of insulin.

A study was conducted to check the bioavailability of Glipizide in patients who were suffering from ...