DISCUSS THE PROCESS OF PROTEIN SORTING AT THE ENDOPLASMICRETICULUM?

Discuss the process of protein sorting at the endoplasmicreticulum?

Discuss the process of protein sorting at the endoplasmic reticulum?



Secretory proteins are transported from their place of synthesis, the endoplasmic reticulum (ER), their correct final destination through the secretory pathway in the EU-karyotic cells. This process is initiated by the export of correctly folded and assembled secretory proteins from the EPR in the Golgi apparatus (Schekman and Orci, 1996). It was assumed for years that the Director-Tory protein sorting occurs only after the arrival or exit from the Golgi compartment. Thus, the secretory proteins will travel with the ER to the Golgi (Griffiths and Simons, 1986). In principle, this opinion is due to the fact that many secretory proteins are found in all the Golgi cisterns in immunocytochemistry and their oligosaccharides modified in similar man-ner of Golgi enzymes (Griffiths and Simons, 1986). However, there is still no adequate explanation as to why different proteins receive different glycosyl modifications in the Golgi, with the exception of the modification of lysosomal enzymes (Nishikawa et al., 1997).

Only a few experiments in the name of the point of whether the secretory and / or plasma membrane proteins travel together with the Golgi apparatus. VSVG and HA two viral glycoproteins are transported through the SE-cretory ways in different regions of the plasma membrane in the kidneys of dogs Madin-Darby (MDCK) cells. The fact that these two glycoproteins can be localized in the same tank Golgi has led to speculation that they are secretory proteins are transported from their place of synthesis, the endoplasmic reticulum (ER), their correct final destination through the secretory pathway in the EU-karyotic cells. This process is initiated by the export of correctly folded and assembled secretory proteins from the EPR in the Golgi apparatus (Schekman and Orci, 1996). It was assumed for years that the Director-Tory protein sorting occurs only after the arrival or exit from the Golgi compartment. Thus, the secretory proteins will travel with the ER to the Golgi (Griffiths and Simons, 1986). In principle, this opinion is due to the fact that many secretory proteins are found in all the Golgi cisterns in immunocytochemistry and their oligosaccharides modified in similar man-ner of Golgi enzymes (Griffiths and Simons, 1986). However, there is still no adequate explanation as to why different proteins receive different glycosyl modifications in the Golgi, with the exception of the modification of lysosomal enzymes (Nishikawa et al., 1997).

Only a few experiments in the name of the point of whether the secretory and / or plasma membrane proteins travel together with the Golgi apparatus. VSVG and HA two viral glycoproteins are transported through the SE-cretory ways in different regions of the plasma membrane in the kidneys of dogs Madin-Darby (MDCK) cells. The fact that these two glycoproteins can be localized in the same tank Golgi has led to speculation that they are sorted only during or after passage through the Golgi, but not before (al Rindler et ...