Article Summary

Article Summary

Carter, Paul & Wells, James A. 1988, Dissecting the catalytic triad of a serine protease, Nature 332, 564 - 568

In the article “Dissecting the catalytic triad of a serine protease” written by Paul Carter & James A. Wells they analyzed the catalytic action of serine peptidases depends on the interplay of a nucleophile, a general base and an acid. In the classic trypsin and subtilisin families this catalytic triad is composed of serine, histidine and aspartic acid residues and exhibits similar spatial arrangements, but the order of the residues in the amino acid sequence is different. By now several ...