ABCB1 GENE

ABCB1 Gene

ABCB1 Gene

This paper presents an executive summary on the topic of ABCB1 gene, its position and its function. ABCB1 gene is a constituent of the ATP binding cassette (ABC) Transporter super-family. The gene is renowned as multidrug opposition 1 (MDR1) gene and its protein merchandise called P-glycoprotein (P-GP). ABCB1 is conveyed in barricade and excretory tissues, shielding or elimination of purposes, for example the intestines, liver, kidney, blood-brain barricade and placenta. ABCB1 over sign in tumors have been engaged in multidrug opposition to cancerous infection chemotherapeutic agents. Located on the plasma membrane, P-GP can present a broad variety of ...