Understanding of Epigenetic Can Help in Pain Management

Understanding of Epigenetic Can Help in Pain Management

Introduction

The paper details out the major nursing progress and nursing researches that have been carried out on the epigenetic of fetal, cardiovascular, cancer and the pain management. These researches remained fruitful in understanding the depth of nursing epigenetic and its effectiveness in diagnosis and treatment and patient care.

Major Studies in Epigenetic

Fetal/Neonatal

Initially, the knowledge of the fetal and neonatal issues in the context of epigenetic was unknown, but gradually, the nursing researches facilitated this knowledge by carrying out the fruitful clinical researches. The major change that nursing has brought into fetal epigenetic is by identifying that the health of mother and nutrition is significant to the well being of the unborn child. The new sate of the art screening techniques has been developed to examine the effect of the folic acid intake at the time of pregnancy on the status of fetal epigenome. This data ensured provision of sufficient data to the national policies regarding the maternal nutrition and supplementation.

According to a research by Anthony et el (2011), the high resulting epigenetic profiling of the folic acid is associated with the birth weight in humans. This paper was carried out by the nursing Epigenetic research group and it was found that the folic acid supplementation during pregnancy reduces the risk of neural tube defects and low weight of the infant during birth. This is one of the major nursing findings which facilitate the neonatal treatment of the women who are at health risk during pregnancy (Anthony et el,2011). According to a study “Epigenetic regulation and fetal programming” conducted by Gicquel ET el (2008), programming encompasses the role of a high association between the poor fetal growth and the chronic adult disease. The current observations in humans and the experimental studies on rodents suggest that the epigenetic alterations in the regulatory genes and growth related genes play an important role in the fetal programming (Gicquel, El Osta, Le Bouc, 2008,1-16). Such observations have helped the nursing studies to inentifythe possible gene regulatin and devise the strateges of treatment.

Xu (2010) conducted a research on “Epigenetic in neonatal diseases” and it was found that there is an increase of epidemiological disease like type 2 diabetes mellitus, hypertension, and cardiovascular disease. The fetal origin of the adult diseases is strongly related with the epigenetic modification of genes. A role of the epigenetic modification in the transient neonatal diabetes mellitus (TNDM), congenital disorders, pulmonary hypertension of the newborn (PPHN), and intrauterine growth retardation (IUGR), have been studied (Xu, Du, 2010,2948-2954). It was found that the role of this epigenetic modification in the neonatal disease is conducive to better understand the pathogenesis of these diseases and to provide new insight for the treatment and prevention of the adult diseases.

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