TARGET ORGAN TOXICOLOGY

Target Organ Toxicology



Target Organ Toxicology

Target Organ

Target organs are those organs that are more likely to suffer from high blood pressure, even if it is high blood pressure you cannot feel. The target organs are only those vital organs in our body that are the main affected in any change to occur. The secrete hormones that do not quite understand because the target organs do not secrete any hormones. These target organs include heart, liver, lungs, brain, eye and kidney (Tyson & Sawhney, 2005). For all these organs requires close monitoring, because watching some changes from year to year in the dynamics. Target organs are called because they are the first affected when changes occur.

Target Organ Toxicity

Target organs can be examined by exposure to intact organisms, and a detailed analysis of the function and histopathology in the target organ, or in vitro effects on cells, tissue sections or whole organs that are supported within a short time in. In some cases, toxicology studies of target organs can be used by tissues of the human body, which may justify the assumption of interspecies extrapolation. However, it should be borne in mind that such studies do not provide information about the relative toxic kinetics (Turton & Hooson, 1997). In general, toxicology studies of target organs have the following common features a detailed histopathological examination of the target organ, including the data post-mortem studies, weighting the body and study of fixed tissue, biochemical studies of the critical paths of contact with target organ such as the important enzyme systems, functional studies possible organ and cellular components to carry out the expected metabolic and other functions, and analysis of biomarkers of exposure and early effects in the cells of target organs.

Role of the Liver in the Detoxification Process

The phenomena leading to the removal of unwanted compounds from the circulation or the tissues are known as detoxification. Most people do not realize how important this process is and how big part in it is the liver. With the current state of the environment and the amount of preservatives present in the daily diet, the liver has a more difficult task. Unwanted substances should be in one way or another expelled from the body, whether the urine or bile. These processes depend on the physical characteristics of toxins (NIEHS, 2002). Those that are well soluble in water are usually quite quickly excreted into the bile or urine, to then leave the body in the feces. Contrast, fat-soluble molecules to a much greater extent may be cumulative, and thus more influence on biochemical processes, as their elimination is associated with the processing of other compounds, usually less active and more soluble in water. Organ, in which there is very much this type of reaction, is the liver.

Its role in detoxification is so important because the vast majority of the volume of blood from the placenta back to the visceral circulation wrotnymi vessels, which are aimed directly into the cavity of the ...