Processes of Suppositories

Processes of Suppositories

Filling and Heat-Sealing Suppository Shells

The process of filling and heat sealing suppository shells yields important considerations. These considerations must always be kept in mind while filling and heat sealing suppository shells. We will discuss the considerations in detail throughout the text. First of all the mixture for filling suppository shells is prepared through an orthodox mechanism. Once the mixture is ready to be filled, it is than filled in the suppository shells (The Pharmaceutics & Compounding Laboratory, 2013).

The vital consideration while filling the mixture is to ascertain that the suppository mixture should be solidified in order to prevent the rise of cavity being produced. The suppository mixture can be filled through a beaker or a syringe.

It has been observed that the syringe allows more control and thus the suppository mixture should be filled in shells by making use of Syringe. Our aim in filling the suppository mixture is to solidify it to a great extent. Once it has been solidified than we can move on to the stage of heat sealing suppository shells (The Pharmaceutics & Compounding Laboratory, 2013).

The heat sealer strip plays an important role in the process of heat sealing of suppository shells. This heat sealing process consists of a two step process. First of all a hot air gun is used in order to shrink each side of the shell openings. The hot air gun is necessary for this process since without getting the sides shrinked, we perform the process of sealing the suppository shells.

The important consideration in this step is not to overheat and melt the suppositories. There have been many instances where the individuals have been guilty of overheating the suppository. As a result, the suppositories got melted and were of no use later.

The hot air should be focused on the top of the shells and not on the center or the end. The heat sealer is then used to seal the shells. The process of filling and heat sealing of suppository shells concludes with the sealing of suppository shells through a heat sealer.

Determining the Density Factor Using the Double Casting Technique

Density Factor is considered to be a significant determinant in the production of suppositories. The Density factor can be measured either through calculation or the double casting method.

We will focus on the use of double casting technique as a determinant of density factor. First of all the plain suppositories without drug have to be transferred to the mould. We have to remove the suppositories and ascertain the average weight of them (The Pharmaceutics & Compounding Laboratory, 2013).

The first casting process involves pouring the drug mixture into the mould as well as filling to the top of the mould with a plain suppository base. The red color has been highlighted in order to ascertain the level of drug used in the suppository base. It has been observed in the first casting process that the holes were partially filled when the drug ...