Poor Concentration & PCOS



Poor Concentration & PCOS

Statement of the Research

Polycystic Ovarian Syndrome causes concentration and focus problems

Description of the Data

PCOS, which is also known as the polycystic ovary syndrome, is a hyperandrogenic disorder associated with chronic oligo-anovulation and polycystic ovarian morphology. It is often associated with psychological impairments, including depression and other mood disorders and metabolic derangements, chiefly insulin resistance and compensatory hyperinsulinaemia, which is recognized as a major factor responsible for altered androgen production and metabolism. Most women with PCOS are also overweight or obese, further enhancing androgen secretion while impairing metabolism and reproductive functions and possibly favoring the development of the PCOS phenotype. The definition of PCOS has led to an impressive increase of scientific interest in this disorder, which should be further directed to improve individualized clinical approaches and consequently therapeutic strategies.Defining alterations of steroidogenesis in PCOSIn normal women, androgen production rate (PR) is the result of adrenal and ovarian secretion and conversion from precursors in peripheral tissues, particularly the adipose tissue and skin. Similarly, the metabolic clearance rate (MCR) of androgens may occur in both glandular and extra-glandular tissues. Both PR and MCR of androgens in female depends on age and physiological status. All androgens exhibit a daily rhythm, less variable for androstenedione and testosterone than that of dehydroepiandrosterone (DHEA) and cortisol. A few studies, all performed several decades ago, documented higher PR's for both androstenedione and testosterone in women with PCOS, associated with a less pronounced increase in their MCR. In addition, it was shown that testosterone MCR was higher in obese PCOS women and varied according to its PR, whereas MCR of androstenedione was marginally different with respect to normal weight affected women, suggesting that factors (peripheral conversion or possibly binding to sex hormone binding globulin) in addition to body size influenced testosterone MCR in PCOS women. Notably, there are no studies in PCOS women with different obesity phenotypes, although there is evidence that in women with simple obesity, those with abdominal fat distribution have higher testosterone PR, but not higher androstenedione, with respect to those with the peripheral phenotype. Similar studies should therefore be replicated in PCOS women with different obesity phenotypes. Oestrogen and progesterone PR's in women with PCOS have been poorly investigated.One of the main problems in the diagnosis of hyperandrogenic states such as PCOS is the accurate measurement of androgens and particularly testosterone. Many radioimmunoassays, especially platform assays, for androgens are decidedly unsatisfactory. Most of these intrinsic methodological limitations are bypassed by the growing use of liquid chromatography-tandem mass spectrometry (LM/MS-MS), the modern gold standard for all steroid hormone measurement, particularly in women. By the use of LM/MS-MS, it would be expected that additional kinetic studies in different phenotypes of this disorder might favor a better understanding of complex pathophysiological events leading to androgen excess in women with PCOS, as preliminary clinical studies seem to indicate.

Significance

It can also be estimated that 25 percent of testosterone and androstenedione production is said to be the origin of ovary, adrenal origin is of 25% and peripheral tissues is ...