PHASE I REACTIONS OF METABOLISM OF FOREIGN SUBSTANCES

Phase I reactions of metabolism of foreign substances



Phase I reactions of metabolism of foreign substances

Metabolism occurs via two types of reactions: phase I and phase II. The goal of metabolism is to change the active part of medications (also referred to as the functional group), making them more water-soluble and more readily excreted by the kidney. (ie. the body is trying to get rid of the “foreign” drug) Changing the molecular structure of drugs increases their water solubility and decreases their fat solubility, which speeds up the excretion of the drug in the ...