OUTCOME ON OBESITY ON FEMALES

Outcome On Obesity On Females

Outcome On Obesity On Females Age 21-30

The results of the two-way analysis of variance showed that the group in which seizures were induced and then treated with acepromazine displayed significantly [F (1, 54) = 15.22, P < 0.001] heavier body weights (M = 322 g, SD = 37 g) compared with the other groups (M = 284 g, SD = 35 g) 7 weeks after the treatment (100 days of age). Within 4 weeks (130 days), the seized s given acepromazine were still significantly [F (1, 54) = 24.95, P < 0.001] heavier (M = 408 g, SD = 94 g) compared with the other groups (M = 350 g, SD = 91 g). These two main effects explained 22 and 32% of the variance in the body weights, respectively. Neither the main effect for differences between ages at the time of injection [Fs (1, 53) < 1.00, P > 0.05] nor the interactions [Fs (2, 53) < 1.00, P > 0.05] between age of injection and postseizure treatments were statistically significant.

The statistically significant differences [F (3, 16) = 6.69, P < 0.01; ?2 = 0.50] between the four conditions for weights 28 weeks after the single treatments on Postnatal Day 35 were shown by post hoc analysis to be due to the significantly heavier body weights displayed by the s that received the acepromazine after seizure induction (M = 461, SD = 26) compared with either the normal s (M = 337, SD = 15) or those that received lithium/pilocarpine and did not seize (M = 341, SD = 44). The group that received chlorpromazine (M = 424, SD = 34) occupied an intermediate position. Six of the s that displayed seizures and then received acepromazine and three of s that seized and then received chlorpromazine displayed spontaneous seizures that began about 2 weeks after the initial induction. The two s that did not seize following lithium/pilocarpine injection did not display spontaneous seizures. There were no significant differences in body weights between the groups during the first 4 weeks after treatment.

By far the most impressive effect occurred with advanced aging. At 62 weeks after treatment, s that had seized and had been given the single injection of acepromazine were more than twice as heavy (M = 777 g, SD = 136 g) as their littermates (with whom they had been housed for a year) who had been either (1) only handled (M = 385 g, SD = 7 g), (2) injected with lithium/pilocarpine but not seized (M = 380 g, SD = 34 g), or (3) seized but given a single injection of ketamine (M = 446 g, SD = 79 g). The s that seized and received the acepromazine all exhibited spontaneous seizures. The ketamine-treated s were never observed to display this behavior. None of the five s that were injected with lithium/pilocarpine but did not seize were observed to display spontaneous seizures over their lifetimes.

There was no overlap in the body weights between the s that seized and received acepromazine and s from any of the other three groups. An example of a that received acepromazine after seizure induction and a littermate that received ketamine after seizure induction. Post hoc analysis of the statistically significant differences between postseizure treatments [F (3, 9) = 14.72, P < .001; ?2 = .83] indicated that the seized acepromazine s were significantly heavier than the other three groups, which did not differ significantly from each other. There were no significant differences in body weights between the two densities in which the s lived for more than a year ...