NONCARDIOGENIC EFFECTS OF STATINS

Noncardiogenic Effects of Statins



Abstract

Statins is a group of drugs that are used to lower cholesterol level in blood. This drug works to inhibit the enzyme HMG-CoA reductase. Statin is immensely effective in the treatment of various noncardiogenic diseases too, such as cancer, dementia, chronic kidney disease, and stroke. This research aims to analyze the noncardiogenic effects of Statins. The research is delineated by the assistance of a thorough research on the secondary data available on the subject. The material presented provides a holistic view of Statin and its noncardiogenic effects. Statin reduces the probability of having cancer. The people who take Statins have a reduced chance of having kidney related diseases as men who do not take such drugs. In 1971, Dr. Akira Endo, who worked in Tokyo, suggested that the metabolic products of fungi that grow on nutrient media (penicillin for better quality) must also contain natural inhibitors of cholesterol synthesis and thus he developed Statins. Statins drug is also useful in reducing the chances of Stroke in people. Statin helps to keep the blood vessels healthy and reduces the chances of dementia. Researchers have found evidence that people, who are currently taking Statins, may rarely get cancer, kidney diseases, dementia, and Stoke.

Table of Contents

Introduction3

Noncardiogenic Effects3

Cancer and Kidney Diseases3

Dementia and Stroke3

Literature Review4

History4

Effects on Cancer5

Effects on Chronic Kidney Diseases5

Effects on Dementia5

Effects on Stroke6

Benefits of Statins7

Side Effects of Statins7

Discussion8

Researches and Discussion on Cancer8

Researches and Discussion on Chronic Kidney8

Researches and Discussion on Dementia9

Researches and Discussion on Stroke9

Conclusion10

References11

Noncardiogenic Effects of Statins

Introduction

Statins is a group of drugs that is used to lower cholesterol level in blood. This drug works to inhibit the enzyme HMG-CoA reductase. Statin is immensely effective in the treatment of various noncardiogenic diseases such as cancer, dementia, chronic kidney disease, and stroke.

The first Statin was isolated from the mold Penicillium citrinium by Akira Endo and Masao Kuroda of Japan in 1976. Now innumerable people have strongly recommended using Statins. Statins is the most commonly sold and used drugs. The research aims to analyze the noncardiogenic effects of Statins.

Statins is selective and reversible HMG-CoA reductase inhibitor as it inhibits the conversion of HMG-CoA to the precursor sterol, mevalonate and thus reduces the synthesis of cholesterol in hepatocytes. This results in increased expression of the gene for LDL receptors and thus greater uptake of the particles of LDL. This lowers total cholesterol and LDL cholesterol in the blood. In addition to reducing the level of cholesterol, it also reduces VLDL, apolipoprotein B and triglycerides. It has various noncardiogenic effects too.

Noncardiogenic Effects

Cancer and Kidney Diseases

Statin reduces the probability of having cancer. It has now been confirmed following an analysis of 23 studies involving over 41,000 patients using Statins. Statins constituent a group of drugs prescribed to lower the blood cholesterol levels. Lipitor, Zocor, Pravachol, Crestor is part of this group of drugs. The analysis was published in the American Journal of Cardiology. A study involved about 120,000 nurses and other health care workers who were followed for 15 years. It concluded that Statin results in reduced chances of cancer.

In another study, 277 people who were diagnosed with kidney related diseases and 66 of whom took Statins at the time of ...