The genus Neisseria contains the number of species, some of which are part of usual human flora and others which are obligate pathogens of humans and animals. Neisseria are Gram-negative diplococci. Pili on surface of bacteria bind to CD46, an abundant human support C3b/C4b-binding cell surface glycoprotein. This allows pathogens to enter owner units, where they can endure and grow. Diagnosis of gonorrhea is therefore routinely presented by visualization of Gram-negative diplococci inside leukocytes (white body-fluid cells). This video shows the clinical specimen of urethral pus showing Neisseria gonorrhoeae (purple dots) with the background of leukocytes and protein debris: