NANOPARTICLES

Nanoparticles Used As A Drug Delivery System for an Anti-Cancer Agent



Nanoparticles Used As A Drug Delivery System for an Anti-Cancer Agent

This essay is based on the case study dealing with nanoparticles used as a drug delivery system for an anti-cancer agent. In this essay we will be covering the main concepts covered in the case study.

Paclitaxel Content in the Nanoparticles

Paclitaxel proved to be much activity against of various solid tumours as breast cancer, advanced ovarian cancer, lung cancer, head and neck cancer and acute leukaemia. However, the success of its clinical use is limited mainly to its low therapeutic index and low water solubility, and many other pharmaceutical solvent for the management of intravascular (V) acceptable.

Alcohol at a ratio of 50: 50 (V / V) is currently only available for clinical use (Taxol ®) the judgment of paclitaxel (6 mg / ml) in the vehicle consisting of Al and dewatered Cremophor ®. This car was associated with Ernst hypersensitivity reactions and incompatibility with the common sets of intravenous administration of PVC. Removing Cremophor ® based vehicle and when the therapeutic effectiveness try alternative dosage forms including parenteral emulsions, liposomes and nanoparticles and micro spheres increase offered.

New drug delivery systems

New drug delivery systems of polymers nanoparticles are seen as a promising anti cancer agent institution. In fact, it was shown that drug specificity of action attach a significant improvement after its inclusion in the nanoparticles that effect are mainly accessible now to changes in the distribution of tissues and pharmacokinetics. These changes can then lead to reduce the side effects and toxicity of the drug and its therapeutic effectiveness increase. It is proven that the nanoparticles can to escape the sewers by leaking endothelial tissue around the tumour and thus accumulate in some solid tumours. Recently, it was also reported that nanoparticles by resistance mediated by a glycoprotein (p) cause phenotype, an increase of drugs within the tumour cells can be overcome. This finding is important for the case since resistance to paclitaxel reported drug purchased. Other important benefits in connection with the use of nanoparticles are easy to prepare with clear biodegradable polymers (ex: LEAD PLGA package) and their high stability in biological fluids and during storage.

Thus the main objective of this work is, polymer delivery system for drug paclitaxel Cremophor ® EL and improve to develop anti tumour of the drug use.

Nanoparticles, the prepared surface deposition method was ...