MUTATION IDENTIFICATION BY SEQUENCING (BRCA2)

Mutation Identification by Sequencing (BRCA2)

Mutation Identification by Sequencing (BRCA2)

Introduction

Breast cancer is the most common malignancy among women in developed countries. It is estimated that about 5-10% of the cases may be due to inherited predisposition, but the exact number of predisposing genes is unknown. Epidemiological studies have provided evidence for at least two genes conferring inherited susceptibility to breast and ovarian cancer, BRCA1 (17q21) (Miki et al., 1994) and BRCA2 (13q12) [1]. BRCA1 accounts for most families with multiple cases of both early-onset breast and ovarian cancer and about 45% of families with breast cancer only [1]. ...