MEDICINE

The Association between Callus Formation, High Pressures and Neuropathy in Diabetic Foot Ulceration

[Name of the Institute]

The Association between Callus Formation, High Pressures and Neuropathy in Diabetic Foot Ulceration

Literature Review

Callus Formation and Diabetic Ulcer Formation

Diabetes is the leading cause of non traumatic amputations of the lower extremities in developed countries, and between 14% and approximately 24% of diabetic patients with foot ulcer should undergo an amputation. However, research has shown that the development of a foot ulcer is preventable. As estimated, in 1995 there were 135 million people worldwide with the disease, a figure has probably increased to 154 million in 2000. By 2025, it is projected that there will be 300 million people with diabetes worldwide. The vast majority of new diagnoses of diabetes is type 2 (non-insulin dependent), with an increase of 42% of cases in developed countries and an increase of 170% in developing countries (Watkins, 2003, p. 977).

The statistics are highlighting diabetes as one of the sever health concerns; therefore, the research studies should focus on the in-depth analysis to identify the causes that might vary from patient to patient. This paper has strived critically evaluating the research findings and clinical approaches used to conduct the research work with around 63 patients of diabetes. The focus is to analyse the feasibility and reliability of this report and to check whether it paves way for future research work or not.

Critical Analysis

The article is critically evaluated in accordance with the instructions and framework set by Greenhalgh.

Diabetic Foot Ulcers

Diabetes can result in the appearance of skin lesions and ulcers in 30% of patients this is because the diabetic disease involvement on vessels, nerves and epithelial tissue. Moreover, patients who are on their own underlying disease are at high risk of infection, causing serious general or local complications (Vuorisalo et. al., 2009, p. 275).

The evidence-based medicine indicates that the research studies should focus on analysing the associated risk of both harm and benefit. This could only have been possible with carefully selected population sample and techniques used to conduct a high quality research that would represent the whole population (Greenhalgh, 2010, p. 1). The diabetics information and literature work done in this article states that diabetic ulcers and diabetic foot clinic are altered and neuropathic etiopathogenic basis induced by maintained hyperglycemia in which, with or without the coexistence of ischemia, and after a traumatic trigger, produces lesion or ulceration of the foot (Jude et. al., 1999, p. 748).

The clinical examination highlighted that occlusive arterial disease was four times higher in the diabetic population than in those without HHT. Although peripheral vascular disease in diabetic patients is the result of accelerated atherosclerosis in whose pathogenesis involves several factors, is similar to that presented no diabetic individuals (Murray et. al., 1996, p. 979).

The clinical research should identify the possible symptoms in patients and observe for cost benefit analysis. This research work reflected that risk factors associated with the development of peripheral vascular disease could be hypertension, microalbuminuria, dyslipidemia, hyperglycemia, and obesity. The research work must provide ...