MALNUTRITION EFFECTS OF FOLIC ACID

Malnutrition effects Lack of folic Acid

Malnutrition effects Lack of folic Acid

Introduction

Folic unpleasant, furthermore known generically as folate or folacin, is a constituent of the B-complex family of vitamins, and works in live performance with vitamin B12. Folic unpleasant purposes primarily as a methyl-group donor involved in numerous significant body processes, encompassing DNA synthesis. Therapeutically, folic unpleasant is instrumental in reducing homocysteine levels and the occurrence of neural tube defects. (Alpert et al, 2002)

Cervical Dysplasia

Research points to an association between folate status in adults and cervical dysplasia; however, its role as an efficacious therapeutic intervention is unclear. One report proposes folic unpleasant supplementation (10 mg folic unpleasant for three months) turns around cervical dysplasia in women taking oral contraceptives. In another study, 154 persons with grade 1 or 2 cervical intraepithelial neoplasia were randomly assigned either 10 mg folic unpleasant or placebo daily for six months. No significant dissimilarities were discerned between supplemented and unsupplemented subjects considering dysplasia status, biopsy outcomes, or occurrence of human papilloma virus type-16 infection. It is possible certain subsets of women (perhaps those with an oral contraceptive-induced deficiency) might be more amenable to treatment; although, additional research is needed to clarify the therapeutic role of folic unpleasant in cervical dysplasia.

Homocysteinemia

An abnormally high plasma grade of homocysteine, the de-methylated derivative of the amino unpleasant methionine, is an unaligned risk factor for cardiovascular disease. bigger plasma homocysteine has been attached to bigger risk of neural tube defects and other birth defects, as well as to schizophrenia, Alzheimer's infection, cognitive decline, osteoporosis, rheumatoid arthritis, kidney malfunction, and cancer. The activated coenzyme form of folic unpleasant (5-methyltetrahydrofolate) is needed for optimal homocysteine metabolism, since it actions as a methyl donor, supplying a methyl group to vitamin B12. The methylated pattern of vitamin B12 (methylcobalamin) subsequently transfers this ...