INTERLEUKIN 6(IL-6)

Interleukin 6(Il-6) In A Lipopolysaccharide (LPS) Model of Neuro-Inflammation

INTERLEUKIN 6(IL-6) IN A LIPOPOLYSACCHARIDE (LPS) MODEL OF NEURO-INFLAMMATION

Section 1

Introduction

Anti-inflammatory CD4+ regulatory cells (TREG) function to restore immune homeostasis during chronic inflammatory disorders. It is widely believed, however, that TREG function mainly to suppress protective neuro inflammatory responses. Thus roles for inflammation, TREG cells, and bacteria are paradoxical and are the subject of controversy. Our accumulated data build upon the “hygiene hypothesis” model in which infections lead to changes in TREG that reduce inflammation-associated diseases. Ability of TREG to inhibit or suppress depends upon bacteria and IL-10, which serve to maintain immune balance and a protective anti-inflammatory TREG phenotype. (Weiner, 2007, 1380)

The cause's inflammation of the nerves can cause bacteria and viruses, inflammation of the nerves, as well as lack of food, vitamins, and infectious diseases such as tuberculosis, syphilis and herpes, which can sense the invasion of the nerve. It can also be generated when it alters nerve inflammation disease such as diabetes, the activities of the body's cells. Can also occur because of inflammation of the nerve injury includes organic nerve injured nerve. The disease gout and Allukimia and methyl alcohol poisoning with heavy metals such as lead, mercury, cadmium, and arsenic may cause this disease. Disease, inflammation of the nerves occurs at any age in both sexes but the proportion of it occurs in men more than women and this disease occurs in men between the ages of thirty and fifty. (Wang, 2009, 79)

Definition of interleukin 6

Interleukin 6 (IL-6) is a multifunctional cytokine which produce both lymphoid and non-lymphoid cells and which regulates the immune response, ostrofazny inflammatory response and haematopoiesis. One of the main functions of IL-6 is the regulation of the maturation process of antibody-producing cells of B-lymphocytes and immunoglobulin's of the product itself. IL-6 is also involved in the activation of T lymphocytes. IL-6 can induce the synthesis of many ostrofaznyh proteins: fibrinogen, al-antihimotripsina, al-acid glycoprotein, haptoglobin, serum amyloidal A, CRP, a1-antitrypsin and a2-macroglobulin. Production of albumin at the same time decreases. With the development of acute-phase levels of IL-6 in blood serum correlates with the level of CRP and the level of a neuro-inflammation patient. Increased IL-6 in serum may precede the rise in the level of CRP. (Dissing, 2007, 112)

Between pro-inflammatory cytokines, which are characterized by synergistic effect, there are quite complex, the classifying vzaimnoreguli relationship. In particular, IL-6 inhibits the production of IL-1 and TNFa, which are both active inducers of the synthesis of IL-6. In addition, IL-6 through the hypothalamus-pituitary regulatory element enhances the production of cortical, which, in turn, acts on liver cells, increasing the induction of 1L-6 ostrofaznyh proteins, but inhibits the gene expression of IL-6, as well as genes of other pro-inflammatory cytokines. (Christensen, 2006, 181)

Effect Of Interleukin 6 on Lipoplysaccharide

Interleukins, for example, vary considerably in their antigenic structure, and the logical grouping is due to the receptor capacity, and accordingly - common signal transmission. Unlike endocrine hormones, cytokines (proteins or glycoproteins with ...