Rachel McAdams ("The Notebook," "Wedding Crashers") plays Lisa Reisert, a young hospitality director for a major hotel in Miami. Departuring for home from a funeral in Texas, the film opens with her rushing to the airport to catch the last flight of the night - the 'red eye' of the film's title. Lisa is a multitasker, used to dealing with high stress in a calm and rational manner. Lisa is clearly independent, but still daddy's little girl. Dad must think his daughter can do everything but land a man, as he has slipped yet another Dr. Phil book ...