IMPACT OF DRUG TRANSPORTER

Impact of Drug Transporter

Word Count: 1952Impact of Drug Transporter

Introduction

After the publication of the new information related to the human genome and their function in 2001, there was quite a major breakthrough in the drug related strategies. Changes in the procedure of drug development as well as drug discovery were also seen at large. The transporters of drugs are presented in great number of tissues like liver, intestine, brain and the kidney; it plays a major role in the drug distribution, absorption and excretion (Sun,Dai,Shaik & Elmquist, 2003 pp 84). The information related to the functional characteristic of drug transporters is very important for the further improvement of the drug design or drug delivery by specifically targeting transporters proteins.

The functional uses of transporter provide the possibility of the delivery of drug to the specific organ therefore reducing the toxic side effects related to it. It also controls the removal procedure plus improves on the bioavailability which is oral. So it a vital, that the compound which is related to the lead are not exposed to the transporter. The Transporter way of expression of system is quite well organized, plus uses an efficient way for finding out the activity of single transport procedure. The change brought up in the drug-drug interactions and genetic polymorphisms, which also includes transporters. This can directly effect on the usefulness of many major drugs and therapeutic safety.

Discussion

Drug Discovery

This process of drug development can be classified into two categories. One of them is Pre clinical, the new molecular entities are compounds, which emerge from the process. The field related to the pharmacology, medicine and biotechnology, the process in which new candidate medication are brought to light are called drug discovery. Initially the drugs were developed by the identification of the active ingredients in different medicines. Later on the progress was made, which promoted the chemical libraries of extracts natural products or small molecules were screened in whole organism or intact cell to identify ingredients that have favorable therapeutic effect in a way known as Classical Pharmacology (Sun,Dai,Shaik & Elmquist, 2003 pp 84). After the human genome sequencing which led to the development of synthesis of large quantities of purified proteins and rapid cloning, it has now become a common practice to use high through put screening of huge compound libraries against small biological targets which are hypothesized that they can modify disease in a process known as reverse pharmacology.

Drug Development

Drug development is the process of bringing in new medicine into the market. The process of drug development is a result after the process of drug discovery (Stouch & Gudmundsson, 2002 pp 317). It involved the clinical trials and pre-clinical research, one of the products is built the next step is the taking of approval from the regulatory bodies. Once the approval is given than formally, the development takes place.

These are the drugs which have shown promising features when they are tested in the laboratory. They are tested within the controlled environment, so ...