ENTEROHEPATIC RECIRCULATION

Enterohepatic Recirculation

Enterohepatic Recirculation

Enterohepatic Recirculation

Enterohepatic circulation is the excretion of a drug (or a metabolite of it) through the bile to be re-absorbed in the gut and sent again to the liver along the portal vein, so the excretion-reabsortion cycle can start again. Due to this process, some molecules not too toxic as such may become extremely hepatotoxic as they can reach unexpectedly high hepatic concentrations or prolonged permanence in the entero-hepatic system. Recycling through liver by excretion in bile, reabsorption from intestines into portal circulation passage back into liver, and re-excretion in bile (Timbrell, 2001, 52-201).

Enterohepatic circulation Process

Enterohepatic ...