ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR

Endothelium Derived Hyperpolarizing Factor

Endothelium Derived Hyperpolarizing Factor

Introduction

The role of endothelium derived hyperpolarizing factor is quite high in the case of patients who suffer from hypertension, diabetes and heart problems. The vascular endothelium release a diffusible factor that hyperpolarizes and makes the vascular muscles relaxed because of the activation of various channels. During the heart circulation, the endothelium derived hyperpolarizing factor appears to be an arachidonic acid epoxide, which plays a vital role in the maintenance of heart blood flow in arteries. (Needham, 2005)

The endothelium even plays a crucial role in vascular homeostasis by releasing various autacoids. The basal synthesis of these autacoids produces a great effect because of the increase in the cell deformation which creates independent stimuli known as hypoxia. Apart from this cellular release, one of the most interesting thing that happens is the formation of various acids in the body that cab cause a major impact in the body. These acid reactions must be noticed properly that takes place in the human body, but it is essential that all the enzymes must not harm the whole human body. Here is a figure which clearly shows the different acidic movements and enzymes reactions that takes place in the body of human beings. (Balk, 2003)

Main Body

In the last 10-15 years, there is considerable evidence which clearly accumulates the research that has gathered huge amount of data regarding endothelium derived hyperpolarizing factor. The different acidic movement that takes place inside the body causes deep impact on the various portions of heart. However, when the acidic movement does not take place, so then there is a relaxation in the human body and the heart even remains safe but this condition does not remain for very long. (Swartz, 2000)

There is a concept of synthesis that normally smooth out muscle cell hyper polarization and it even blocks the mind process where all the signals come in. Although, there is no role of brain in this whole process but sometimes the effects of heart are so strong that it even affects the brain of the human body. Therefore, this problem can get very serious and can even cause huge damage to the brain of the person. (Liu, 2004)

Recently, the major debate has taken place which has raised the issue of the identity of this disease and its principle which some researchers have named it EDHF that is known as "eternally deceptive relaxing factor." There are several experimental problems which have taken place and has even sparked the debate that whether the acidic movements that takes place in the human body is due to one major reason that is EDHF or some other reasons. (Williamson, 2003)

The various changes that takes place in the brain due to EDHF has been observed in various experiment which has created many results but majority of them have proved that EDFH plays a vital role in the development of acidic movements that affects the portions of the heart in human body which in turn produces ...