DYSFIBRINOGENEMIA

Dysfibrinogenemia

Dysfibrinogenemia

Introduction

Dysfibrinogenemia is a heredity disease and is also termed as the deficiency of factor I (fibrinogen). This disease is caused if there is a problem with the factor I, and it is a bleeding disorder.

The term factor I, is associated with several disorders and the congenital disorders which is also known as fibrinogen. The disease associated with it is Afibrinogenemia which is a complete absence of fibrinogen and hypofibrinogenemia which is a result of low levels in the fibrinogen. These diseases have either, the high or low amount of blood in it, which means that in any case amount of blood is abnormal in it. The term dysfibrinogenemia is considered, as the defect in the amount of fibrinogen, and it does not perform the functions which it should perform. Along with all these terms, hipodisfibrinogenemia is a combination of both low level and high levels of fibrinogen, and it has some alterations in fuction.

Afibrinogenemia is a disorder which is transferred to children if both parents are suffering from the defective genes and then this gene is passed to their children. This is a disorder which is most commonly found in those areas of the world where mostly marriages are between close relatives. The disorders of Hypofibrinogenemia, dysfibrinogenemia and hipodisfibrinogenemia, are transferred either recessive which means that both mother and father have the defective genes, or dominant which means that either mother or the father is carrying and transmitting the defective genes. All the diseases associated with factor I, affect both genders i.e. male and females.

Symptoms

The symptoms of the dysfibrinogenemia disorder are not same in all the patients; it varies from patient to patient depending on their conditions. The main bleeding symptom is Afibrinogenemia.

Common Symptoms

Main symptoms of dysfibrinogenemia disorder are heavy or prolonged menstrual periods, nosebleeds, muscle bleeds, after circumcision bleeding, bleeding from the umbilical cord stump at birth, susceptibility to bruising, during pregnancy problems, abnormal bleeding during or after injury, surgery or childbirth, in mouth bleeding after surgery or tooth extraction and etc.

Other symptoms reported

Along with the common symptoms, there are also some other symptoms of dysfibrinogenemia disease. These symptoms are mainly, Hypofibrinogenemia, bleeding in central nervous system, Haemorrhage in viscera (gastrointestinal bleeding), problem in the brain and spinal cord and blood clots (thrombosis).

Symptoms vary from the trends in which they are operating the fibrinogen (in normal concentrations). It is said that some people facing with this disease, do not have any symptoms, whereas, other people have symptoms like bleeding (this is also seen in afibrinogenemia), and some have the symptoms of thrombosis which is a result of abnormal blood clots in blood vessels, and they do not suffer from bleeding.

Diagnosis

There are different forms of diagnosis for the Dysfibrinogenemia disorder; these types include the blood tests. From these blood tests, there is a test which is used to find the fibrinogen amount in the blood. Before the treatment, a complete diagnosis should be done so that the physician can recommend ...