Dong Quai Root



Abstract

Herbs are an important aspect of traditional Chinese medicine, as well as a rich source of unique chemicals. Among the medicinal herbs, Dong Quai is the most popular used in Chinese medicine. The main compounds found in the acetone extract of Dong Quai (AS-AC) are ferulic acid, ligustilide, brefeldin A, butylidenephthalide, and polysaccharides, the latter with potential therapeutic effect on various human cancers. Based on molecular evidence from in vitro and in vivo studies, we discuss here how butylidenephthalide suppresses tumor cell proliferation and promotes tumor cell apoptosis. The molecular mechanisms involved include butylidenephthalide-stimulated translocation of Nur77 from the nucleus to the cytoplasm, leading to tumor apoptosis. Butylidenephthalide likewise suppresses telomerase activity, resulting in tumor senescence. Finally, a controlled release system can increase localized butylidenephthalide concentration. Importantly, butylidenephthalide can cross the blood-brain barrier. Current evidence suggests its efficacy against brain tumors and therefore potential clinical applications. Proven for centuries to treat a wide range of female complaints, Angelica sinensis is, Chinese called dong quai, in Asia, also known as the "Ginseng for Women". Chinese women take Dong Quai to regulate her menstrual cycle and relieve painful menstrual cramps (spasms). Modern herbalists recommend dong quai for premenstrual syndrome and the harmonization of the natural cycle after stopping the pill, but also for all the problems associated with the hormonal changes of menopause. The root of dong quai has been nicknamed the “female ginseng” because of its health aiding qualities and natural healing qualities.  Many of the uses of dong quai are primarily useful for the female reproductive system. This natural herb has been used primarily in Asian countries for thousands of years and is often combined with other herbal medicines to aid in fertility, reproduction issues and other female organ related situations.

Dong Quai Root

Introduction

For centuries, natural plant remedies (many of them obtained from herbs) have been used to treat disease and maintain health, especially in China. More than 3200 herbs and 300 minerals (and even animal extracts) are routinely applied to patients as a mixture or formula. Practitioners of traditional Chinese medicine believe that disease primarily arises from imbalances in the body (Xie, Zhang et al. 2006). The therapeutic purpose of a Chinese doctor is therefore to bring the human body back into equilibrium. Herbal drugs are used with the goal of restoring this balance by nourishing the body, including the energy, qi (breath circulation), and spirit, to maintain health rather than to treat a particular disease or medical condition. This mindset reflects an emphasis on preventive medicine. Treatments undertaken with this goal are called Fu Zheng and are given as complementary therapy intended to reduce the side effects of conventional Western medical treatment. Chinese herbal medicine is independent of conventional Western concepts of medical diagnosis and treatment.

One aspect of Chinese medicine is to bolster resistance to disease by strengthening a person's immunity. Chinese herbs attempt to prevent and treat physiological imbalances, such as those caused by cancer and other diseases, with combinations of herbs, minerals, and plant ...