COMPLEMENTARY SYSTEM

Complementary System

Complementary System

Q-1 Explain why serum IgM cannot activate complement by itself?

IgM cannot activate the complement by itself as the process requires binding of antibodies with the antigens. (Freeman, 2005)

Q-2 Would you expect a C1 or C3 complement deficiency to be more serious clinically? Why?

Yes.

Reason: Patients who have the deficiency of C1 inhibitor often have the problem of Hereditory Angiedema. It further affects the hands mouth, bowel and feet as they result in swelling. If the bowel gets affected by the swelling then it can cause serious abdominal pain. The swelling in the airways is extremely serious because ...