A chemical reaction is a transformation of matter in which the chemical species (atomic or molecular ion) that make up matter to be changed: the species that can be eat is called reagents. Species formed during the reaction going to be called as products (reaction). Since the work, of Lavoisier (1777), scientists know that the chemical reaction takes place without measurable change in mass. "Nothing is lost, nothing is created, everything transformed" which reflects the conservation of mass.
Chemical reactions cause a change in the chemical nature of matter, excluded purely physical changes, such as changes of state (melting, solidification, evaporation, ...