Article Summary

Article Summary

In this article, Pauling states that the ground state of the enzyme substrate convoluted is shown to be associated to the transition state through the signify force portraying along the answer path; as such, catalytic schemes will not be settled into ground state destabilization versus transition state stabilization.

Pauling contrasts the function of active-site residues in the chemical step with the analogous function performed by solvent substances in the natural environment of the noncatalysed reaction. We resolve that enzyme catalysis is considerably enhanced by the proficiency of the enzyme to preorganize the answer environment. This complementation of the enzyme ...