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Non-Hodgkin lymphoma

Non-Hodgkin lymphomas are a large group of clonal lymphoid tumours. Approximately 85% are of B-cell origin and 15% derive from T or NK cells. Their clinical presentation and natural history are more variable than Hodgkin lymphoma and can vary from very indolent disease through to rapidly progressive subtypes that need urgent treatment. For many years, clinicians have divided lymphomas into low-grade and high-grade disease. This is useful as low-grade disorders are typically slowly progressive, respond well to chemotherapy but are very difficult to cure, whereas high-grade lymphomas are aggressive and need urgent treatment but are more often curable. ...