ANNOTATED BIBLIOGRAPHY ON CHICANOS AND DIABETES

Annotated Bibliography on Chicanos and Diabetes

Annotated Bibliography on Chicanos and Diabetes

Mandler R, Goren H, ValenzuelaR. Value of central tense scheme IgG every day synthesis conclusion in the diagnosis of multiple sclerosis. Neurology. 1982 Mar;32(3):296-8.

Purpose

Using laser beam immunonephelometry, we verified the worth of Tourtellotte's equation in the diagnosis of MS.

Sample

Moreover, since immunonephelometry presents several benefits, encompassing ease, rapidity, and precision, it is a undertaking technique for the diagnosis of MS.

Methods

Complex dimensions are not essential. Determinations take only minutes.

Results

The results are reproducible. Mathematics manipulations are easy with gladly available computers.

Valenzuela R, Mandler R, GorenH. Immunonephelometric quantitation of centered nervous scheme IgG every day synthesis in multiple sclerosis. Clinical evaluation using predictive worth theory. Am J Clin Pathol. 1982 Jul;78(1):22-8.

Purpose

With a laser nephelometric immunoassay and an empirical equation for the quantitation of centered tense scheme (CNS) every day IgG synthesis.

Sample

We researched prospectively a population of 101 persons split up into four assemblies: 31 normals, 25 patients with definite multiple sclerosis (DMS), 18 patients with likely or possible multiple sclerosis (PMS), and 27 patients with neurologic infection other than multiple sclerosis (NMS).

Methods

By the Kruskal-Wallis, check the results of the DMS and PMS patients were considerably distinct from the normals and NMS patients (P less than 0.0003).

Results

Considering normals, DMS, and NMS patients only, the sensitivity of the test was 96%, the specificity was 98%, the positive predictive value was 96%, the negative predictive value was 98%, and the efficiency was 98%. Based on our study data, we applied the predictive value theory to different hypothetical populations (our Neurology Ward, Northeastern U. S., and patients with optic neuritis and chronic progressive myelopathy). In all these positions, the check provided a diagnostic efficiency for multiple sclerosis larger than 95%.

Mandler, Biddison, Mandler, Serrate S. beta-Endorphin augments the cytolytic undertaking and interferon output of natural murdered cells. J Immunol. 1986 Feb 1;136(3):934-9.

Purpose

We have enquired the in vitro consequences of the neurohormone beta-endorphin (b-end) on natural murdered (NK) undertaking and interferon (IFN) output mediated by large granular lymphocytes (LGL).

Sample

LGL-enriched fractions from peripheral blood mononuclear cells (PBMC) from normal human volunteers were got by fractionation over discontinuous Percoll gradients.

Methods

LGL were preincubated with or without various concentrations of b-end or the closely associated peptides alpha-endorphin (a-end), gamma-endorphin (g-end), or D-ALA2-beta-endorphin (D-ALA2-b-end), a synthetic b-end analogue. NK undertaking was assayed on 51Cr-labeled K562 goal cells. Preincubation of LGL effectors (but not K562 goals) for 2 to 18 hr with concentrations of b-end between 10(-7) M and 10(-10) M made important augmentation of NK cytolytic activity (mean percentage boost: 63%).

Results

The classic opiate antagonist naloxone blocked the enhancing effect when used at a 100-fold molar surplus relation to b-end. Neither a-end neither g-end could augment NK undertaking, while D-ALA2-b-end made an enhancement comparable with that made by b-end. In addition, incubation of LGL with b-end in the presence of phytohemagglutinin or poly I:C considerably augmented IFN production.

Implications

These findings illustrate that b-end enhances NK activity and IFN production of purified LGL, and proposes ...