Skeletal formation in mice over their life span and their contribution towards the understanding of human skeletal development

Skeletal formation in mice over their life span and their contribution towards the understanding of human skeletal development

Introduction

Scientific discovery and research has engrossed human beings from the very beginning of time. When man realized that education is vast and never ending and there is a reason behind almost every activity that occurs in this world, the concept of scientific research occurred. Since then, scientists and researchers have spent a lifetime trying to deduct causes for different phenomenon. Some researchers have been successful in their cause and some have perished in the effort.

Mice have always been the most preferred test subject for scientific researches. Possibly, their skeletal structure and their anatomy is the closest match to the human body (in terms of formation and DNA structure), which is why scientists have proven that the results extracted from tests on mice yield extremely accurate results when applied to human beings.

The skeletal structure of a mouse (a phenomenon that is still explained and absolutely amazing) is almost the same as a human being. It displays extremely similar characteristics and traits. This is the main reason why scientists have based majority of their research pertaining skeletal structure and development, on mice. In this paper, we shall focus on the researches done on the skeletal structure of mice and how they have impacted scientific research and medical breakthrough for the treatment of human skeletal structures (Yasutomi, 2012).

Discussion

Much of our knowledge of the cartilage and bones comes from the descriptive anatomy, endocrinology and cellular studies of bone metabolism and structure in mice. Recent studies identify local factors that regulate morphogenesis of the skeleton. Mollekulyarnye and biochemical studies of bone and cartilage cells in vitro, gene inactivation intentional and genes responsible for the anomalies of the human skeleton and mice documented the importance of specific growth and differentiation factors, extracellular matrix proteins, signaling mediators and transcription factors in the development of bone and cartilage.

In general, the latest figures show the need to reflect the development of the skeleton at different levels of the body and illustrate the influence of a single gene on the development of these different levels. Information structure has helped develop various skeletal elements in the human body (WHO, 1994). There are two types of mice that have been categorized for use in scientific researches and development. The first is called the 'knockout mice' and the other type is the 'transgenic mice'. Transgenic mice differ from the knockout ones because the cartilage phase of their bone healing is less, because it lacks a gene known as the tumor necrosis factor alpha (Yahoo, 2001).

Since the early 20th century, researchers started using mice in their labs. However, scientists have realized that genetically mutated mice are much better for deducing results closer to those of human beings. It helps researchers identify and analyze skeletal structures of mice (and humans) at an extremely micro, genetic level. Transgenic mice (genetically mutated) ...