Coronary Heart Disease Genetics Vs Lifestyle

Coronary Heart Disease Genetics Vs Lifestyle

Introduction

Coronary heart disease (CHD) mainly causes from the interaction between genetic and various life style factors. It has been observed that the coronary heart disease causes with the parents genes as well as with unhealthy lifestyle including eating and sleeping habits. Obesity, smoking, and physical inactivity are considered as the main causes of CHD. Collective evidence shows that types of carbohydrates and fats plays more vital role in determining risk of CHD (Robert, 2011).

Topic Selection

It has long been known that coronary heart disease is mainly caused due to hereditary factors. However it is long debate to decide that whether the increased risk of CHD is through an unhealthy lifestyle in the family or it is transferred through the genes. His topic is selected to analyze that which cause influences more in causing CHD (Robert, 2011).

Coronary Heart Disease Inherited Through Genes

The family aggregation of coronary heart disease is considered as a main source of risk factors. Research shows that children who have their parents suffering from CHD are 40 to 60 per cent more probable of developing this relevant condition themselves.

Mutation and Polymorphisms in Genes affecting Glucose Metabolism

Mutations have been described as a major affect in a number of genes by which glucose metabolism is influenced. One example which leads a child to diabetes is the presence of mutation in the glucokinase gene. The existence of mutations is very rare and due to this influence is much smaller as compare to other causes (http://www.chd-taskforce.de/pdf/sk_genetic_chd.pdf).

Mutations and Polymorphisms in Genes Affecting Homeostasis

Polymorphisms and Mutations have been described in many genes and it affects the clotting system such as plasminogen activator inhibitor. On coronary artery disease risk the outcome effects of these polymorphisms is due to some genes including plasminogen activator inhibitor (http://www.chd-taskforce.de/pdf/sk_genetic_chd.pdf).

Mutations and Polymorphisms in Genes Affecting Cellular Adhesion

In the linkage of circulating blood cells to the arterial endothelium, atherogenesis is considered as an initial step. This mechanism is further preceded within two steps, among them the first one is that which exists in selectin family and causes a movable binding to molecules of it the second one is a tight contraction to intracellular bond molecules, including vascular cellular adhesion molecule (VCAM). The polymorphisms in genes that are considered as the main causes of affecting cellular adhesion are known as probable risk determinants for coronary artery disease (http://www.chd-taskforce.de/pdf/sk_genetic_chd.pdf).

Coronary Heart Disease due to Unhealthy ...